Effective Neuropathy Treatment 

RESTORE ME BENEFITS :

If a medical professional has diagnosed you with neuropathy - the burning, numbness and tingling of your extremities - the ingredients in Restore Me can help alleviate the symptoms that come from damaged nerves. Don’t keep living with the pain of damaged nerves, support your nerves and nervous system with Restore Me.

Neuropathy

Signs of damage to the nervous system generally begins with a loss of reflexes, numbness and a decrease in muscular strength. Over time, increasing damage to the nerve cells will lead to positive signs of neuropathy which is defined more by burning, tingling and biting pain in the extremities. These pains can come on gradually over a period of years, or appear suddenly. Both peripheral and diabetic neuropathy have proved to be very difficult conditions for the medical profession to treat but Restore Me is specifically formulated to support the bodies ability to repair and protect your nerves and thus helps to prevent neuropathy.
Your body naturally produces Glutathione (GSH) which is one of the most influential anti-oxidants found in the nervous system, liver, and kidneys. It is the primary defense against toxins which heavily contribute  to neuropathy.  Because GSH is weakened by stress, painkillers, and overconsumption of refined foods, it is especially important for people with diagnosed neuropathy to find the means to boost its productivity. The micronutrients NAC, vitamin C, selenium, and ALA (Alpha-Lipoic Acid) found in Restore Me stabilizes and energize GSH, reestablishing a crucial balance or surplus of healthy cells which allows GHS to do its job, regardless of the source of the neuropathy.
The other ingredients in Restore Me that contribute to the potential reduction of neuropathy is its highly bioavailable B vitamins. Vitamin B deficiency caused by diet or inherited genetic mutations can also be a contributing factor in neuropathy. While Vitamin B is crucial to healthy GSH production and is found in a variety of common foods, sometimes our bodies are not able to convert or deliver them in an efficient bioavailable form for GHS production. Homocysteine  (HCY) is an amino acid which your stomach releases in the normal part of the digestive process. Homocysteine is a regular by-product of the Methionine cycle, a major contributor to our everyday metabolic processes.  However, as are so many systems and cycles within the human body, there is a fine balance between too much and the “right” amount of HCY. Too much sustained over a period of time can contribute to a number of significant conditions and diseases.  A simple blood test can measure your body’s HCY level.  Elevated levels are a recognized risk factor for many neurological conditions, including neuropathy. These elevated levels of HCY are often associated with deficiencies in folate, vitamin and vitamin B12.  A defect in the MTHFR gene can contribute to an elevated HCY level as well.  Supplementing with the high bioavailability ingredients in Restore Me can help balance HCY levels in your diet.

ADVANTAGES OF BIOACTIVE FOLATE (5- MTHF)

COMPARED TO ORDINARY FOLIC ACID

DIETARY FOLATE

(Impairs final step in activation of folate.)

MTHFR C677T GENOTYPE

ORDINARY FOLIC ACID

DIHYDROFOLATE

TETRAHYDROFOLATE

5, 10-METHYLENETETRA- HYDROFOLATE

5-METHYLTETRAHYDROFOLATE

5-METHYLTETRAHYDROFOLATE

(No Metabolic Conversion Required.)

5-METHYLTETRAHYDROFOLATE

Figure: Folic acid requires several activation steps before it can be used by cells. The Bioactive supplement, 5-methyltetrahydrofolate (5-MTHF), is equivalent to the active form of folate used by the body. Unlike ordinary folic acid supplements, it is unaffected by the MTHFR variant genotype and requires no conversion or activation.

N-acetylcysteine (NAC)

• N-acetylcysteine (NAC) is precursor to glutathione, a free radical scavenger & inhibitor of TNF-a.
• Oral NAC reduced decline of motor nerve conduction velocity in diabetic rats. Structural analysis of sural nerve showed significant reduction of fibers undergoing myelin wrinkling & inhibition of myelinated fiber atrophy.
• NAC treatment had no effect on blood glucose levels or on nerve glucose, sorbitol & cAMP contents.
• NAC corrected decreased glutathione levels in RBCs, increased lipid peroxide levels in plasma & increased lipopolysaccharide-induced TNF-a activity in sera of diabetic rats. Sagara, M., et al. Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with NAC. Diabetologia. 39(3):263-269, 1996.

Impact of the MTHFR Mutation. Some neuropathy can be traced back to a genetic explanation or root cause. One type of genetic explanation is associated with the MTHFR mutation. MTHFR is the abbreviation for Methylenetetrahydrofolate.  (Hence the abbreviation!).  Unofficial reports state that up to 60% of the Caucasian population is probably affected.  These mutations affect every person differently leading to different gradients of symptoms. Importance of Methylfolate. Methylfolate is the bioactive form of folic acid. The availability of methylfolate allows other B vitamins and influential micronutrients  access to the methylation cycle. Together with Pyidoxal-5-Phosphate as vitamin B6 and methylcobalamin as vitamin B12, methylfolate reduces inflammatory homocysteine.  Homocysteine levels have been found to be significantly elevated in patients with diabetic neuropathy. Reduction of homocysteine levels helps to protect nerve endings while reducing damage to blood vessels. Because all of these vitamins are formulated to be administered in a form that is easier for the body to absorb, improvement in nerve fiber density and a reduction in the frequency of painful sensations or numbness occur more quickly. It is comforting to note that the discovery and understanding of the importance of adding methylfolate through supplementation your body access to folate in its most useable form.   Restore Me offers all of its B vitamins in the most useable, bioactive compounds. The Metafolin®  in Restore Me is one of the best methylfolates available for dispensing in capsules.

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**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.